When the concentration was increased to 100 μM, there was more than a 2‐fold increase in the number of edema cases (P2‐P4) of which 37.5% had mild edema (P2) and 8.3% had moderate to severe edema (P3‐P4); however, this increase did not reach statistical significance ( p = 0.1114, Figure 4A ).
The intravascular fluorescence intensity showed a trend towards further reduction (11% decrease) when compared with the group that was only treated with the Kmo inhibitor; however, this was also not statistically significant (Figure 4D ). 3.4 KMO Inhibition Impacts Cell Shape, Size and Focal Adhesions in Cultured Human and Murine Podocytes Since the zebrafish larvae show signs of proteinuric kidney disease after KP dysregulation, we analyzed the effects of KP inhibition on cultured glomerular cells.