Distinct IRF6 dysfunction mechanisms in syndromic orofacial clefts: Computational evidence for allosteric versus direct disruption.

Comput Struct Biotechnol J · 2025 · PMC12615309 · PMID 41245888

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hedged sentences

0.0720

closest p · 1.4× alpha

0.7800

boldest claim

The sentences

approaching significancep = 0.072so close (0.05 < p ≤ 0.1)

The wild-type complex exhibited substantial inter-replica variability (SD = 3.42 Å), while one-way ANOVA revealed marginally significant differences among systems (F(2,9) = 3.28, p = 0.085), with the NP_006138.1 :p.(Arg84Cys)- NP_006138.1 :p.(Ala16Val) comparison approaching significance (p = 0.072).

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marginally significantp = 0.085so close (0.05 < p ≤ 0.1)

The wild-type complex exhibited substantial inter-replica variability (SD = 3.42 Å), while one-way ANOVA revealed marginally significant differences among systems (F(2,9) = 3.28, p = 0.085), with the NP_006138.1 :p.(Arg84Cys)- NP_006138.1 :p.(Ala16Val) comparison approaching significance (p = 0.072).

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did not reach statistical significancep = 0.78not close (p > 0.1)

Although these differences did not reach statistical significance (Kruskal-Wallis, p = 0.78), the trends were highly consistent across all four independent replicas.

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