Barely Significant
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Evaluating the safety and efficacy of rapid bolus-only dexmedetomidine for pediatric EEG sedation: a retrospective study.

Eur J Pediatr · 2025 · PMC12627106 · PMID 41251877

2
hedged sentences
0.0950
closest p · 1.9× alpha
0.0950
boldest claim

The sentences

showed a trendP = 0.095so close (0.05 < p ≤ 0.1)
Patients with upper airway abnormalities were more likely to require additional doses ( P = 0.001) and showed a trend toward increased adverse events ( P = 0.095).

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Although this trend did not reach statistical significance, it aligns with existing evidence indicating that pediatric patients with OSA have increased anesthesiological risk due to their heightened sensitivity to sedative and opioid medications, which can exacerbate airway obstruction and respiratory depression [ 20 – 22 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.