Acute experiences and persisting psychological effects associated with an encapsulated DMT-harmala alkaloid combination: results of a phase 1 study.

In a separate analysis restricted to the formulation “C” subgroup, similarly no dose-dependent relationships were observed for MEQ ( p = 0.106), SIME ( p = 0.273); however, the MEQ result again showed a trend toward significance.

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Specifically, in the analysis across the full dataset total dose (mg) was not a significant predictor for MEQ ( p = 0.109), 5D-ASC ( p = 0.736) and SIME ( p = 0.810), although a trend toward significance was apparent for the MEQ.

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Specifically, the highly purified formulation “C” showed positive moderate/strong correlations with SIME (significant) and MEQ (approaching significance), while less purified formulations (“A” and “B”) demonstrated consistently negative correlations ( r = − 0.35 to − 0.42), although not reaching significance.

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standard) was consistently positively correlated with mystical experience scores, with SIME close to significance.

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