Potential drug targets for chronic obstructive pulmonary disease in the plasma proteome identified through Mendelian randomization.

BMC Pulm Med · 2025 · PMC12641967 · PMID 41286868

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did not reach statistical significanceno p-value reported

In contrast, ERAP2 (OR = 0.98, 95% CI: 0.95–1.01, P = 0.23) and SNX1 (OR = 0.93, 95% CI: 0.87–1.00, P = 0.06) did not reach statistical significance.

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nominally significantno p-value reported

Meta-analysis provided robust evidence for IL27RA (OR = 0.97, 95% CI: 0.95–0.98, P = 1.0×10-6) and TIE1 (OR = 1.14, 95% CI: 1.07–1.21, P = 4.8×10−5), while IL17RD was nominally significant.

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