Multicenter Translational Trial of Remote Ischemic Conditioning in Acute Ischemic Stroke (TRICS BASIC).

The mean infarct volume at 48 hours (Table 4 ; Figure 2 B) did not significantly differ in RIC+ mice compared with RIC− mice in the unadjusted analysis (27.8 versus 32.5 mm3; mean difference, −4.7 [95% CI, −10.2 to 0.9]; P =0.097), but this difference reached borderline significance in the sex-stratified analysis ( P =0.051).

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The percentage of mice achieving a favorable functional outcome at 48 hours, defined as a score of <20 in the De Simoni composite neuroscore, was higher in the RIC+ group (49%) compared with the RIC− group (28%), but this difference reached a borderline significance level in the unadjusted analysis (absolute difference, 21%; odds ratio, 2.5 [95% CI, 0.97–6.1]; P =0.058) or when stratified by sex ( P =0.052).

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Similarly, the proportion of rats with a favorable functional outcome at 48 hours was higher in the RIC+ group (62%) compared with the RIC− group (42%), but this difference also did not reach statistical significance in the unadjusted analysis (absolute difference, 20%; odds ratio, 2.2 [95% CI, 0.92–5.5]; P =0.074) or in the sex-stratified analysis ( P =0.073).

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The 2 parallel trials were analyzed separately by species, and results were combined in an overall analysis if 1 trial showed a borderline significant P value.

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