SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence.

Nat Cancer · 2025 · PMC12643927 · PMID 40999053

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did not reach statistical significanceno p-value reported

showed a trendno p-value reported

RUNX1 showed a trend toward higher signal in lung metastases but did not reach statistical significance at the analyzed number of samples (Extended Data Fig. 8d ), implying that KLF4 status has a dominant role in the human setting.

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