Characterization of the mutational landscapes in Japanese patients with early-onset colorectal cancer from comprehensive genomic profiling data.

Furthermore, in line with previous findings, high- amplification of FLT3 showed a trend towards worse overall survival.

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Interestingly, a more pronounced difference was observed between the prognosis of FLT3 -high and FLT3 -low amplification subgroups among patients with FLT3 and CDK8 co-amplification; however, the difference did not reach statistical significance (Supplementary Fig. 2 ).

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