Adverse events of postoperative adjuvant chemotherapy predict survival outcomes in locally advanced colorectal cancer: a pooled analysis of Japanese clinical trials.

However, in the UFT/LV for 6 months subgroup, patients with Grade 2 or Grade 3 adverse events, and in the mFOLFOX6 for 6 months subgroup, those with Grade 1, exhibited a trend toward poorer OS than Grade 0, although these differences did not reach statistical significance.

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In contrast, among those receiving double-agent therapy, Grade 1 showed a trend toward poorer OS compared to Grade 0 (HR: 1.31 [95% CI: 0.38–4.56]), though this difference was not statistically significant.

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