Impact of total neoadjuvant therapy regimens on radiation-induced lymphopenia in locally advanced rectal cancer: a retrospective analysis.

J Radiat Res · 2025 · PMC12648072 · PMID 41250916

Europe PMC DOI

hedged sentences

0.0510

closest p · 1.0× alpha

0.0930

boldest claim

The sentences

a strong trend toward significanceP = 0.051so close (0.05 < p ≤ 0.1)

Although this association was not consistently retained in multivariable analysis, pre-TNT ALC showed a strong trend toward significance ( P = 0.051) at the V15 threshold and achieved statistical significance in sensitivity analyses.

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a trend toward significanceP = 0.051so close (0.05 < p ≤ 0.1)

Small bowel irradiation (V15 Gy > 104 cc) predicted severe lymphopenia during chemotherapy in the univariable analysis; but multivariable analysis suggested pre-TNT ALC as the main factor, showing a trend toward significance ( P = 0.051).

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showed a trendP = 0.093so close (0.05 < p ≤ 0.1)

In the LCCRT–CNCT group, large bowel irradiation (V35 Gy > 46 cc) was significantly associated with severe RIL in univariable analysis but not in multivariable models ( P = 0.227), and in an exploratory combined analysis of LCCRT–CNCT and INCT–LCCRT, this showed a trend ( P = 0.093).

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