Determinants of QTc Interval Prolongation in Patients with Hypopituitarism and Other Pituitary Disorders.

Biomedicines · 2025 · PMC12649990 · PMID 41301770

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.0800

boldest claim

The sentences

did not reach statistical significancep = 0.07so close (0.05 < p ≤ 0.1)

A higher prevalence of craniopharyngiomas, Rathke’s cleft cysts, and congenital central nervous system (CNS) malformations was also observed in patients with hypopituitarism; however, the overall distribution of pituitary pathologies prompting clinical evaluation did not reach statistical significance, although it approached the threshold ( p = 0.07).

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showed a trendp = 0.08so close (0.05 < p ≤ 0.1)

Age (OR = 1.05, 95% confidence interval (CI) 1.01–1.09, p = 0.03), a history of neurosurgery and/or radiotherapy (OR = 2.82, 95% CI 0.86–9.19), and IGF-I SDS (OR = 2.70, 95% CI 0.55–13.19) were identified as potential positive predictors of QTc prolongation, although the latter two associations only showed a trend toward statistical significance ( p = 0.08 and 0.06, respectively).

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