Knocking Out Rap1a Attenuates Cardiac Remodeling and Fibrosis in a Male Murine Model of Angiotensin II-Induced Hypertension.

Cells · 2025 · PMC12651711 · PMID 41294886

Europe PMC DOI

hedged sentences

0.0001

closest p · 0.0× alpha

0.0621

boldest claim

The sentences

highly significantp < 0.0001actually significant

For ventricular weight (VW), two-way ANOVA revealed a highly significant effect of AngII treatment ( p < 0.0001), increasing VW compared to saline controls.

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did not reach statistical significancep = 0.0621so close (0.05 < p ≤ 0.1)

The collagen content in WT AngII treated hearts was nearly double that of WT Saline treated hearts, though this difference did not reach statistical significance ( p = 0.0621).

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showed a trendno p-value reported

AngII treatment showed a trend toward lowering blood glucose levels, though not significantly.

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a nonsignificant trendno p-value reported

Body weight remained unchanged across groups, and AngII showed a nonsignificant trend toward lowering blood glucose, consistent with reports of enhanced insulin sensitivity [ 39 , 40 , 41 , 42 ].

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