SOX9, GATA3, and GATA4 Overexpression in Liposarcomas: Insights into the Molecular Biology of Adipocytic Sarcomas.

Int J Mol Sci · 2025 · PMC12652793 · PMID 41303462

Europe PMC DOI

hedged sentences

0.1500

closest p · 3.0× alpha

0.5590

boldest claim

The sentences

did not reach statistical significancep > 0.15not close (p > 0.1)

Although these differences did not reach statistical significance ( p > 0.15), the recurrent separation of survival curves suggests an underlying biological gradient that may become apparent in larger, adequately powered cohorts.

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failed to reach statistical significancep = 0.559not close (p > 0.1)

Similarly, GATA3 expression demonstrated a non-significant trend toward increased risk (coefficient = 0.0049, p = 0.486), while GATA4 expression appeared inversely related to hazard but also failed to reach statistical significance (coefficient = –0.0047, p = 0.559).

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a favorable trendno p-value reported

Kaplan–Meier analysis revealed no statistically significant survival differences for individual gene expression, but a high combined GATA3–GATA4 signature was associated with a favorable trend.

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