Cellular and Extracellular MicroRNA Dysregulation in LRRK2-Linked Parkinson's Disease.

Using Pearson’s correlation, we observed a moderate positive relationship between library fold changes and RT-qPCR measurements in material derived from the L1 lines, that fell just short of statistical significance ( r (11) = 0.55, p = 0.052, R 2 = 0.30) (Fig. 3 D).

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In EVs derived from the L1 lines, the difference in pRab10/tRab10 ratios showed a trend toward higher values in the mutant line, though it did not reach statistical significance ( t (10) = −1.84, p = 0.096) (Fig. 2 B).

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