The prognostic and clinical utility of circulating tumor DNA in diffuse large B-cell lymphoma: a systematic review and meta-analysis.

NPJ Precis Oncol · 2025 · PMC12660778 · PMID 41310404

Europe PMC DOI

hedged sentences

0.0100

closest p · 0.2× alpha

0.1200

boldest claim

The sentences

showed a trendp < 0.01actually significant

Compared to other NHL subtypes, DLBCL showed a trend toward higher cfDNA levels, reaching significance only against FL ( p < 0.01), but not HL ( p = 0.20) or MCL ( p = 0.08) (Fig.

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did not reach statistical significancep = 0.12not close (p > 0.1)

Although a trend towards a stronger prognostic value at EOT was observed, the difference between interim and EOT assessments did not reach statistical significance ( p = 0.12).

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