Impact of common variants on brain gene expression from RNA to protein to schizophrenia risk.

Consistently, we observed significant translational and post-translational attenuation of eQTL effect across all PhastCons score strata on top of a clear trend of decreased QTL effect size as the evolution conservation scores increase (Fig.

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To further reduce the number of false positives, for each potential omics-specific QTL identified at 10% FDR we further test genotype association with the other two omics-types and remove any variant that has nominally significant association.

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