Induction of Lupus T Cell Subset by Probiotics-Matured Tolerogenic Dendritic Cells.

Food Sci Nutr · 2025 · PMC12666596 · PMID 41334229

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did not reach statistical significanceno p-value reported

IL‐10 expression increased but did not reach statistical significance.

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showed a trendno p-value reported

Probiotic‐treated groups showed a trend toward increased GATA3 and IL‐4 expression compared to the LPS group in both cohorts, but these changes were not statistically significant (Figure 7 ). 4 Discussion This study demonstrates that Lactobacillus rhamnosus and Lactobacillus delbrueckii induce tolerogenic dendritic cells (DCs) that enhance regulatory T cell (Treg) induction and suppress pro‐inflammatory Th17 and Th1 responses in systemic lupus erythematosus (SLE).

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