Mice carrying the homologous human shelterin POT1-L259S mutation linked to pulmonary fibrosis show a telomerase deficiency-like phenotype with telomere shortening with increasing mouse generations.

Genes Dev · 2025 · PMC12667383 · PMID 40954016

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did not reach statistical significanceno p-value reported

showed a trendno p-value reported

Of note, heterozygous Pot1a +/L261S mice also showed a trend to have shorter telomeres compared with wild-type mice, though the difference did not reach statistical significance ( Fig. 1 G).

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