Gut microbiota signatures in tuberous sclerosis complex and epilepsy: a pilot study.

However, Weighted Unifrac distance (panel C) showed a trend toward distinct clusters between HC and TSD (raw p -value = 0.035, adj p -value = 0.105) and to a lesser extent between HC and EPI (raw p -value = 0.074, adj p -value = 0.111).

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Regarding beta-diversity, although the differences did not reach statistical significance, we observed a trend toward clustering of TSC and EPI individuals, distinct from HC, consistent with existing literature suggesting an epilepsy-associated gut dysbiosis ( Peng et al., 2018 ).

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