Effects of immune checkpoint inhibitors on the pulmonary circulation in lung cancer patients.

Int J Cancer · 2026 · PMC12670334 · PMID 40913348

Europe PMC DOI

hedged sentences

0.2190

closest p · 4.4× alpha

0.2190

boldest claim

The sentences

did not reach statistical significancep = .219not close (p > 0.1)

19 months), though this difference did not reach statistical significance ( p = .219).

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showed a trendno p-value reported

However, in subgroups with squamous cell carcinoma (SCC), stage III disease, and PD‐L1 expression level subgroups (>50% and 1–49%), although OS and PFS showed a trend toward shortening in the severe group, the differences were not statistically significant.

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may not be significantno p-value reported

These findings suggest that ICIs may influence coagulation function in lung cancer patients, but their impact on PFS may not be significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.