Switching from alteplase to tenecteplase for stroke thrombolysis: short-term effects on treatment metrics and early functional outcomes.

BMC Neurol · 2025 · PMC12670721 · PMID 41331749

Europe PMC DOI

hedged sentences

0.0880

closest p · 1.8× alpha

0.0880

boldest claim

The sentences

did not reach statistical significancep = 0.088so close (0.05 < p ≤ 0.1)

The proportions of patients with “golden hour” IVT and with a DTN time < 30 min were larger in the TNK compared to the rt-PA group, but did not reach statistical significance ( p = 0.088 and p = 0.147).

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showed a trendno p-value reported

Still, the higher ICH rate and the higher mortality in the TNK group may be interpreted as a signal of harm, especially because the multivariate analysis showed a trend for the association of TNK with sICH and mortality when adjustment for EVT as a covariate was performed.

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