Baseline AHR expression shapes immune response to pharmacological modulation in PBMCs from pancreatic cancer patients.

3.4 AHR modulation differentially affects monocyte polarization in PDAC PBMCs Analysis of monocyte subpopulations revealed that M0 monocytes remained unchanged across all treatment conditions in both AHR expression groups ( Figure 5A ), with values consistent with those of healthy PBMC and co-cultured baselines, except for Carbidopa, which showed an increasing trend in both patient groups.

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Kaplan–Meier survival curves ( Figure 9 ) showed a trend toward improved survival in the High/Medium AHR group; however, the difference did not reach statistical significance (log-rank p = 0.276).

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PGE2 levels ( Figure 2D ) remained statistically unchanged across all conditions but showed a modest increase following Carbidopa treatment in the High/Medium AHR group and a decreasing trend after BAY treatment in the Low AHR group, moving marginally toward levels found in cultured healthy PBMCs.

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