Comparative effectiveness of antidiabetic therapies on hepatic decompensation in patients with type 2 diabetes: A target trial emulation.

JHEP Rep · 2025 · PMC12682120 · PMID 41362712

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a favorable trendno p-value reported

22 While SGLT2i use was associated with a significantly lower risk, GLP-1RAs demonstrated a favorable trend (HR 0.86; 95% CI 0.73–1.01), narrowly missing statistical significance.

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showed a trendno p-value reported

In the per-protocol analysis (1,151 events), GLP-1RAs (HR 0.43, 95% CI 0.22–0.82) remained strongly protective, while SGLT2is showed a trend toward reduced risk (HR 0.61, 95% CI 0.33–1.12).

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did not reach statistical significanceno p-value reported

Relative to sulfonylureas, GLP-1RAs were associated with a substantially reduced risk (HR 0.43, 95% CI 0.22–0.82), whereas SGLT2is showed a trend toward reduced risk that did not reach statistical significance (HR 0.61, 95% CI 0.33–1.12).

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