Adjunctive Thrombolytics After Successful Endovascular Reperfusion: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Ann Neurol · 2025 · PMC12682943 · PMID 40799167

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did not reach statistical significanceno p-value reported

Although our meta‐analysis demonstrated a statistically significant benefit of adjunctive IAT in achieving excellent functional outcomes (mRS = 0–1), the effect was less pronounced and did not reach statistical significance for the broader category of good outcomes (mRS = 0–2).

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failed to reach statistical significanceno p-value reported

Notably, prior randomized trials of IVT have similarly demonstrated a benefit in terms of excellent outcomes (mRS = 0–1) but failed to reach statistical significance for functional independence (mRS = 0–2). 36 , 37 To address potential concerns regarding the inclusion of unpublished data, we ensured that all such datasets were validated by the lead investigators of the respective trials (ANGEL‐ASPECT, PEARL, and DATE), who participated in this pooled analysis.

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