Repurposed antihypertensive drugs for negative symptoms in schizophrenia: A systematic review and meta-analysis.

Psychiatry Clin Neurosci · 2025 · PMC12683620 · PMID 40923586

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showed a trendno p-value reported

16 showed a trend toward fewer AEs in the experimental group, only the former featured an IRR with a CI excluding the null.

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did not reach statistical significanceno p-value reported

While a modest improvement in total symptom severity was observed, pooled effects for specific subscales (positive, negative, and general symptoms) did not reach statistical significance.

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