Risk factors for refractory malignant pleural effusion and the impact on prognosis in non-small cell lung cancer patients with advanced EGFR mutations: a retrospective cohort study using propensity score matching.

Transl Cancer Res · 2025 · PMC12686216 · PMID 41378013

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did not reach statistical significanceno p-value reported

Additionally, owing to the limited number of patients, although there was a trend toward better OS for patients who received TKI combined with systemic chemotherapy as the initial treatment, this did not reach statistical significance in the subgroup analysis.

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showed a trendno p-value reported

Among these patients, those who received systemic chemotherapy in addition to EGFR-TKI therapy showed a trend toward improved PFS and OS.

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