Muscle Loss in Obesity Therapy as a Therapeutic Target: Trial Design and Endpoints for Regulatory Discussions.

J Cachexia Sarcopenia Muscle · 2025 · PMC12686571 · PMID 41362110

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nominally significantno p-value reported

In this subgroup, a nominally significant improvement in walking speed was observed within the per‐protocol population.

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did not reach statistical significanceno p-value reported

Notably, reductions in visceral adipose tissue and hepatic fat fraction were also observed, whilst trends towards decreased intramyocellular and intermuscular fat did not reach statistical significance.

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