Barely Significant
← all excerpts

SUL-138 mitigates accelerated endothelial aging and protects the kidney.

Clin Sci (Lond) · 2025 · PMC12687458 · PMID 41004128

Europe PMCDOI
2
hedged sentences
0.0600
closest p · 1.2× alpha
0.0600
boldest claim

The sentences

did not reach statistical significanceP =0.06so close (0.05 < p ≤ 0.1)
Total NCC protein abundance was higher in EC-KO vehicle-treated kidneys, but this difference did not reach statistical significance ( P =0.06).

also in 111,027 other papers

showed a trendno p-value reported
This was accompanied by augmented mRNA levels of Cdkn1a and kidney injury marker Havcr1 in the kidneys of EC-KO vehicle-treated mice, which showed a trend of down-regulation after treatment with SUL-138 without reaching statistical significance ( Figure 4F–G ). mRNA expression of kidney injury marker Lcn2 and fibrosis marker Col1a1 showed a trend of being increased in EC-KO vehicle-treated mice without reaching statistical significance.

also in 53,322 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.