Barely Significant
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Semaglutide use before single-level lumbar fusion associated with fewer readmissions and 90-day costs.

J Craniovertebr Junction Spine · 2025 · PMC12688301 · PMID 41377827

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a decreasing trendno p-value reported
Although secondary surgical outcomes did not significantly differ between the semaglutide and control cohorts, incidences of SSI exhibited a decreasing trend among semaglutide patients following single-level lumbar fusion.

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CONCLUSIONS The use of semaglutide at the time of single-level lumbar fusion was associated with a significantly decreased risk of readmission within 90 days of surgery and a lower incidence of SSI, although this difference did not reach statistical significance.

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failed to reach significanceno p-value reported
Further, in accordance with the aforementioned studies, the current study also points to a lower average same-day reimbursement and average LOS postoperatively, although this difference failed to reach significance.[ 12 , 13 ] Since this study used a national patient database, several potential limitations exist.

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Furthermore, the findings point to a lower average same-day reimbursement, although this difference failed to reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.