Extracorporeal Membrane Oxygenation in Acute Cardiovascular Care.

Multivariable analysis demonstrated that IABP use was independently associated with a lower risk of pulmonary edema (OR 0.4; 95% CI 0.2–0.7; P=0.001) and showed a trend toward reduced mortality (OR 0.54; 95% CI 0.29–1.01; P=0.06). 51 Furthermore, a meta-analysis of 22 observational studies involving 4,653 adult cardiogenic shock patients treated with VA-ECMO assessed the effect of concomitant IABP on short-term mortality.

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The absolute difference of 9.5% (95% CI −1.3 to 20.1; P=0.09) did not reach statistical significance, and the trial did not establish clear efficacy for ECPR. 17 The INCEPTION trial, a multicenter RCT conducted in The Netherlands, was subsequently published. 18 It enrolled patients aged 18–70 years who had received bystander CPR and presented with an initial shockable rhythm that remained refractory to resuscitation for up to 15 min.

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