Degenerative pathologies on cortical biopsy, dopaminergic depletion, and shunt efficacy in iNPH.

Positive staining for TDP‐43 showed a trend toward association with lower 1‐year K‐MMSE scores (beta [SE] = −9.45 [4.97], p = 0.066), while α‐synuclein‐positivity was not (beta [SE] = −1.34 [6.05], p = 0.825).

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Based on the LMMs, the total cohort exhibited a trend‐level improvement in MMSE at 1 year ( p = 0.068), while the 2‐year improvement did not reach statistical significance (Table 2 ).

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Interaction between Aβ pathology and DAT uptake on postoperative prognosis When the interaction terms between biopsy‐confirmed Aβ pathology and anterior caudate DAT uptake value were tested, a significant interaction effect was observed on 1‐year postoperative K‐MMSE scores, with a trend toward significance at 2 years (Table 4 ).

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