Dual Inhibition of PARP and Akt Induces Metabolic Collapse and Apoptosis in Breast Cancer Cells.

However, in MCF7 cells, capivasertib considerably increased ROS production ( Figure 3 a), whereas in MDA-MB-231 cells, this increase did not reach statistical significance ( Figure 3 b).

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In both cell lines, the combination treatment showed a trend toward diminished energy production, which was confirmed by a decrease in the oxidative phosphorylation ratio and an absence of a compensatory rise in glycolysis ( Figure 6 g,h).

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