Prognostic Value of Hematologic Indices and Composite Models in Anal Squamous Cell Carcinoma Treated with Image-Guided Chemoradiotherapy.

Cancers (Basel) · 2025 · PMC12691201 · PMID 41375039

Europe PMC DOI

hedged sentences

0.0590

closest p · 1.2× alpha

0.4010

boldest claim

The sentences

showed a trendp = 0.059so close (0.05 < p ≤ 0.1)

Integrated models combining nodal status with PLR ± NLR improved risk discrimination: Model A (N + PLR ≥ 150 ± NLR ≥ 3) showed a trend ( p = 0.059), and Model B (N + PLR ≥ 150) reached significance ( p = 0.021; C-index ≈ 0.68–0.69).

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did not reach statistical significancep = 0.401not close (p > 0.1)

Patients with T3–4 tumors showed numerically lower DFS compared with those with T1–2 disease; however, this difference did not reach statistical significance (3-year DFS 54.7% vs. 59.9%; log-rank p = 0.401; Figure 2 a).

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