Insulin Deficiency Exacerbates Muscle Atrophy and Osteopenia in <i>Chrebp</i> Knockout Mice.

The interaction effect between genotype and drug was also marginally significant ( p = 0.062) ( Figure 5 F).

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In contrast, the main effect of the drug (STZ) ( p = 0.067) and the interaction effect between genotype and drug ( p = 0.070) approached significance ( Figure 5 E).

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In the two-way ANOVA assessing total bone volume/tissue volume, the main effect of genotype was statistically significant ( p = 0.0015), whereas the main effect ( p = 0.11) and the genotype interaction ( p = 0.33) did not reach statistical significance ( Figure 4 A–E).

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In the two-way ANOVA evaluating stiffness, only the main effect of drug type ( p = 0.004) reached statistical significance, whereas the main effects of genotype ( p = 0.051) and the genotype × drug interaction ( p = 0.17) did not achieve significance ( Figure 3 C).

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