GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function.

A scatter plot of SNPs with at least nominally significant ( p < 0.05) effects on both BMI and T2D was generated using RStudio with the ggplot2 package, and Pearson correlation between BMI and T2D-associated signals calculated in R using the cor() function.

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8d , left), which led to a near-significant reduction in exendin-4-induced insulin secretion fold (Fig. 8d , right), an effect which agrees with previously published results in a SPHKAP KO mouse model, with increased insulin secretion under glucose alone conditions but dampened incretin responses in islets from these mice 34 .

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