Metabolic Interplay in Acute Lung Injury: PARK7 Integrates FADS1/2-Dependent PUFA Metabolism and H3K14 Lactylation to Attenuate Endothelial Ferroptosis and Dysfunction.

After treatment with different concentrations of DHA, GPX4 expression in MPMECs showed a trend of upregulation at low concentrations and downregulation at high concentrations (Figure S3C,D , Supporting Information).

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These beneficial changes were further enhanced by ALA supplementation, although the additional reduction in MDA did not reach statistical significance.

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