The Comparative Effectiveness of PDE5 Inhibitors and β3 Agonists Versus α-Blockers in Medical Expulsive Therapy for Distal Ureteric Stones: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Cureus · 2025 · PMC12699237 · PMID 41393662

Europe PMC DOI

hedged sentences

0.4600

closest p · 9.2× alpha

0.4600

boldest claim

The sentences

did not reach statistical significancep = 0.46not close (p > 0.1)

13 ± 1.17 days), but these differences did not reach statistical significance (p = 0.46).

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showed a trendno p-value reported

Conclusions The meta-analysis proved that tadalafil showed a trend toward improved outcomes compared to alpha-blockers in the MET of distal ureteric stones of <10 mm, but results are limited by the high heterogeneity and small number of studies.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.