Biomarkers that demonstrated statistically significant correlations or a strong trend ( p < 0.06) in these exploratory analyses were subsequently included in hypothesis-driven multivariable logistic regression models to evaluate their predictive potential for specific cognitive outcomes.
sNFL showed a positive trend for verbal fluency and word list recognition at V2.2 but mixed results for other test results.
Trends toward improvement were also seen in Boston Naming Test ( p = 0.060) and Mini-Mental State Exam ( p = 0.076), suggesting possible gains in language and global cognition that did not reach statistical significance.