Validation of the integral of pain relief as a measure of chronic pain treatment efficacy.

Pain Rep · 2026 · PMC12705064 · PMID 41404364

Europe PMC DOI

hedged sentences

0.0690

closest p · 1.4× alpha

0.0970

boldest claim

The sentences

approached significanceP = 0.069so close (0.05 < p ≤ 0.1)

By contrast, other scales, including days of relief, showed no significant sex differences, although the overall PGIC approached significance (effect of sex: F = 3.421, P = 0.069, partial η 2 = 0.051). 3.7.

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approaching significanceP = 0.097so close (0.05 < p ≤ 0.1)

Moreover, the analgesic effect decreased more slowly, whereas in men, a sharp relief peak was reached at week 4, followed by rapid decrease, with the overall difference approaching significance (PPR effect of time × sex: F = 2.313, P = 0.097, partial η 2 = 0.035).

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