Advantage of Semaglutide: Comprehensive Analysis of Metabolic Impact of Semaglutide-Treated and Pair-Fed Rats.

PF showed a trend toward increased IL‐1β (Figure 5K ), whereas SEMA induced a robust increase in IL‐6 ( p < 0.0001; Figure 5L ) and elevated TNF‐α compared to control ( p < 0.0001), though levels were significantly lower than in PF ( p < 0.0001).

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Glucagon showed a nonsignificant trend toward higher levels in SEMA ( F [2, 29] = 2.547, p = 0.09; Figure 2D ).

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By day 18, however, SEMA showed a strong trend toward higher body temperature compared to PF rats during the early light phase (Figure 6G ).

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