Single-cell transcriptome analyses reveal disturbed decidual microenvironment in women of advanced maternal age.

This analysis provided a critical quantitative link: PRR15 mean expression showed a highly significant positive correlation with the ‘decidualisation’ score (Figure S4M , Spearman rho = 0.943, p = 0.0167) and a highly significant negative correlation with the ‘collagen production’ score (Figure S4N , Spearman rho = −0.943, p = 0.0167, Table S11 ).

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Although these compositional shifts did not reach statistical significance in the small discovery cohort ( p > 0.05, Table S10 ), likely due to high inter‐individual variability as visualised in the sample‐specific proportion plot (Figure S2F ), they provided a strong hypothesis for subsequent validation.

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While EEC2 proportions showed a trend towards an increase in AMA, this was not statistically significant ( p = 0.4, Figure S6E ; Table S10 ), likely due to high inter‐patient variability, suggesting altered cell state rather than expansion drives the EMT signature.

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