Barely Significant
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ETS Family Transcription Factors in Gastric Cancer and the Role of ELF3 in the Core Metaplasia Transcription Factor Network.

Oncol Res · 2025 · PMC12712686 · PMID 41425714

Europe PMCDOI
3
hedged sentences
0.0600
closest p · 1.2× alpha
0.0600
boldest claim

The sentences

showed a trendp = 0.06so close (0.05 < p ≤ 0.1)
Another cyclin gene, CCNE1 also showed a trend for higher amplification frequency in ELF3/HNF4A up-regulated cancers (Student’s t -test p = 0.06).

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highly significantno p-value reported
HNF4A, besides showing a highly significant co-expression with ELF3, has been identified in a study of master transcription factors of gastrointestinal cancers to be a target gene of lineage-defining master transcription factors [ 11 ].

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did not reach statistical significanceno p-value reported
Other less frequently mutated cancer-associated genes such as LRP1B , FAT3 , FAT2 and ERBB4 were also more commonly mutated in the same group of patients with ELF3/HNF4A up-regulation, but differences did not reach statistical significance ( Fig. 8 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.