Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis.

Although individual comparisons between young and old profiles did not reach statistical significance, a consistent trend emerged across multiple enzymes of the pathway.

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However, 3 days after 5-FU wash out, aged organoids showed a trend towards an increase in apoptosis (Fig. 3f ), in line with the morphology analysis (Fig. 3b,c ).

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