Histamine H3 Receptor Antagonist, Thioperamide, Improves Behavioral and Neuropathological Changes Associated with Subclinical Hypersensitivity to a Cow's Milk Allergen.

J Neuroimmune Pharmacol · 2025 · PMC12717242 · PMID 41417415

Europe PMC DOI

hedged sentences

0.1651

closest p · 3.3× alpha

0.2281

boldest claim

The sentences

did not reach statistical significancep = 0.1651not close (p > 0.1)

However, a direct comparison between overall sex-aggregated sham and BLG-sensitized groups indicated that the difference between the groups did not reach statistical significance (Supplementary Fig. 4-3 , p = 0.1651, Student’s t-test), suggesting that the significant main effect of sensitization was influenced by the combination of sex and treatment factors.

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a decreasing trendp = 0.1837not close (p > 0.1)

Female BLG mice showed only a decreasing trend in the discrimination index in a sex-disaggregated analysis (Fig. 4 h; p = 0.1837, 2-way ANOVA), and thioperamide treatment did not appreciably improve this trend ( p = 0.0924, 2-way ANOVA).

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showed a trendp = 0.2281not close (p > 0.1)

The male BLG group also showed a trend of becoming immobile earlier, although this measurement was not statistically different from the sham group (Fig. 4 d; open vs. filled green bars, p = 0.2281; 2-way ANOVA).

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