A Dual-compartment Scaffolding Role for Receptor for Activate C Kinase 1 in Hepatic Glucagon Signaling and Gluconeogenesis.

However, glucagon-stimulated phosphorylation of CREB at Ser133, pCREB S133 , was significantly reduced in RACK1 fl/fl mice injected with AAV8-TBG-iCre compared with AAV8-TBG-GFP, whereas basal CREB phosphorylation showed a nonsignificant trend toward reduction ( Figure 3 B ).

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Overexpression of the WD1–2 and WD3–4 domains significantly suppressed glucagon-stimulated CREB phosphorylation, whereas basal CREB phosphorylation showed a trend toward reduction that did not reach statistical significance ( Figure 8 C–D ).

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