Oral KDS2010, a Monoamine Oxidase-B (MAO-B) Inhibitor, Slows the Deterioration of Motor Coordination in Genetic SCA1 Models by Inhibiting Astrocytic MAO-B-Mediated Inflammation.

In male mice, the Hetero control group showed only a slight trend toward reduced movement compared to Wild controls, and KDS2010 treatment had no significant effect (Figure 3B ).

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KDS2010 treatment restored the thickness to levels comparable to Wild controls in both sexes, although the effect did not reach statistical significance (Figure 4D,G ).

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The KDS2010 administration group did not improve the hindlimb clasp test in males but showed a trend (Figure 1G,H ).

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