KLF13-mediated CES2 upregulation via p300-dependent acetylation sensitizes gastric cancer cells to irinotecan.

Although our clinical analysis did not reach statistical significance ( p > 0.05), likely due to the limited size of our retrospective cohort ( n = 30), the magnitude of the observed effect is clinically suggestive and aligns powerfully with our in vitro findings.

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A strong trend emerged where patients with high KLF13 expression exhibited a substantially higher objective response rate (ORR) compared to those with low expression (40.0% vs. 6.7%; p = 0.0818, Fisher’s exact test; Figure 1 C, left panel).

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