Neurodevelopmental effects of genetic frontotemporal dementia mutations revealed by total intracranial volume differences.

The main effect of site was significant in its association with education ( F (22,298) = 1.98, p = 0.01, η 2 p = 0.18), birth decade approached significance in its association with education ( F (6298) = 2.06, p = 0.06, η 2 p = 0.04), and there was a group by birth decade interaction ( b = 2.98, SEM = 1.51, t (298) = 1.98, p = 0.049); however, upon inspection, there was no consistent pattern of interest.

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C9orf72 carriers had similar years of education to non-carriers, and a normal positive correlation between TIV and years of education was observed in carriers and trending towards significance in non-carriers.

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