Comparing Functional Consequences of Human iPSC-Microglia and Neural Stem Cell-Derived Extracellular Vesicles in Mitigating Cognitive Decline in Alzheimer's Disease.

Aging Cell · 2026 · PMC12723720 · PMID 41432310

Europe PMC DOI

hedged sentences

—

closest p

—

boldest claim

The sentences

did not reach statistical significanceno p-value reported

A trend for increased synaptic protection that did not reach statistical significance was seen in the PRh.

also in 111,027 other papers

showed a trendno p-value reported

In contrast, the mPFC treated with iMGL‐EV showed a trend toward increased PSD‐95 immunoreactivity that did not reach statistical significance compared to the AD‐Vehicle group. 3.4 hNSC ‐ and iMGL ‐Derived EVs Decrease Proinflammatory Glial Responses in AD Brain The recruitment and activation of microglia and astrocytes in the AD results in a positive feedback loop that leads to a chronically neurotoxic microenvironment (Kim et al. 2018 ).

also in 53,322 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.