Barely Significant
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A proof-of-concept study: investigating the impact of COMT genotype and proline on negative symptoms in Alzheimer's disease.

BJPsych Open · 2025 · PMC12724090 · PMID 41392765

Europe PMCDOI
2
hedged sentences
0.0550
closest p · 1.1× alpha
0.0550
boldest claim

The sentences

a trend toward significancep = 0.055so close (0.05 < p ≤ 0.1)
Results The proline × COMT interaction significantly predicted symptoms as assessed via the negative items of the Positive and Negative Symptom Scale, interaction coefficient 0.025, p = 0.031, with a trend toward significance when assessed via the Scale for Assessment of Negative Symptoms in Alzheimer’s disease, interaction coefficient 0.075, p = 0.055.

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did not reach statistical significanceno p-value reported
trending towards significanceno p-value reported
Although the COMT × proline interaction did not reach statistical significance for all negative symptom assessments, we did observe a significant interaction using the negative items of the PANSS, the one assessment that was used across all our studies, 11 , 12 with interactions trending towards significance when measuring negative symptoms via the SANS-AD total score and the PANSS negative subscale.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.